Welcome!

Bioinformatics continues to provide great advances in how the data from mass spectrometry experiments is propelling the task of drug discovery. One might argue that the key role of a pharmaceutical or biotech company in drug discovery is to produce and manage data. Excellent data provides the researcher with a critical advantage in the pursuit of candidate proteins for development into products of scientific interest: e.g. pharmaceuticals.

Genomic Solutions' proteomic software tools enable researchers to efficiently and easily access protein data: their identity, structure and protein/protein interactions. Leading edge algorithms, high-throughput automation and data management strategies allow researchers to focus on results, not the laborious process of extracting data.

Our systems consist of powerful server applications that can easily be accessed through webbrowsers complemented with client applications for visualisation of reports.

Server applications

KNEXUS is a high-throughput solution to protein identification in small-scale proteomics experiments. This package contains a client application for easy, batch-wise peak annotation, optional recalibration and protein identification from the mass spectra. Per batch a report is created on the client-workstation.

All server applications use the PROFOUND search engine for searching protein sequence from database matches with MALDI spectra, SONAR MS/MS engine for searching protein sequence from database matches with tandem mass spectra and enterprise M/Z to annotate spectra.

ProFound is a search engine for searching protein sequence databases using information from mass spectral peptide maps that incorporates Bayesian statistics to rank the protein sequences in the database according to their probability of generating the experimental data.

Sonar MS/MS is a new software tool for identifying proteins from MS/MS. It contains quality control scoring (Expectation Values), and a brand new graphic delivery for MS/MS data. The bars represent the intensity of the corresponding fragment generated by MS/MS. Only the ion giving the best evidence for that particular fragmentation is represented.

Enterprise M/Z is the first truly automated tool for the analysis of protein and peptide mass spectra. Its novel signal-to-noise based peak finding routines allow it to be applied to strong or weak signals, without user intervention. The peak-modeling algorithm used by Enterprise M/Z allows it to reliably deal with low and high resolution mass spectra, always picking the best peak from an isotope cluster. Its internal structure is flexible enough to represent mass spectra from any type of mass spectrometer, with interfaces to most of the major mass spectrometer file formats.

Client applications All packages contain the client applications: